Dichloromethane → 3-chloro-5-[(4-methyl-2-oxo-1-{2-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]ethyl}-1,2-dihydropyridin-3-yl)oxy]benzonitrile

反応式

[Cl:19][c:20]1[cH:21][c:22]([C:23]#[N:24])[cH:25][c:26]([O:28][c:29]2[c:30](=[O:36])[nH:31][cH:32][cH:33][c:34]2[CH3:35])[cH:27]1.[Cl:56][CH2:57][Cl:58].[O:1]1[CH:2]([n:7]2[n:8][c:9]([CH2:16][CH2:17][OH:18])[c:10]3[c:11]2[n:12][cH:13][cH:14][cH:15]3)[CH2:3][CH2:4][CH2:5][CH2:6]1.[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1>>[O:1]1[CH:2]([n:7]2[n:8][c:9]([CH2:16][CH2:17][n:31]3[c:30](=[O:36])[c:29]([O:28][c:26]4[cH:25][c:22]([C:23]#[N:24])[cH:21][c:20]([Cl:19])[cH:27]4)[c:34]([CH3:35])[cH:33][cH:32]3)[c:10]3[c:11]2[n:12][cH:13][cH:14][cH:15]3)[CH2:3][CH2:4][CH2:5][CH2:6]1