Potassium Carbonate → {5-[(4-Fluoro-benzenesulfonyl)-(3-phenoxy-propyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

関与物質

役割	名称	HCID	仕込み量
反応物	Potassium Carbonate	HCID 11430	—
反応物	Benzene, (3-bromopropoxy)-	HCID 68522	—
反応物	[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester	HCID 67201670	—
溶媒	Water	HCID 962	—
溶媒	Acetonitrile	HCID 6342	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	{5-[(4-Fluoro-benzenesulfonyl)-(3-phenoxy-propyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester	HCID 67199831	—

反応条件

温度	80 °C

反応手順

3-Phenoxypropyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07732618B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-9b49e2a1877e4598b9f303feb4a4778c
出典メモ	uspto-grants-2010_06