関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Phosphoric Acid | HCID 1004 | — |
| 反応物 | Oseltamivir tartrate | HCID 16667738 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Tamiflu | HCID 78000 | 56.3% |
反応手順
Oseltamivir tartrate (13 gm, obtained in example 3) is added to acetone (150 ml) at 25-30° C., the solution of H3PO4 (3.5 gm) in 40 ml of ethanol is added to the contents and then stirred for 1 hour 30 minutes at 25-30° C. Filtered the solid, washed with 30 ml of acetone and dried to yield 6.5 gm of oseltamivir phosphate (HPLC purity: 99.8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07732632B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-958f4ca71a0043ed81f947dbc750f7d2 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
