Resorcinol → 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one
反応式
[Cl:1][CH2:2][C:3](=O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:11]1([CH:18]=CC=[C:14](O)[CH:13]=1)[OH:12]>S(=O)(=O)(O)O>[Cl:1][CH2:2][C:3]1[C:9]2[C:8](=[CH:18][C:11]([OH:12])=[CH:13][CH:14]=2)[O:7][C:5](=[O:6])[CH:4]=1参加物
4
実験手順
Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.
後処理
- temperatureUnder ice-cooling
- filtrationthe precipitated solid was collected by filtration
- washwashed with water
- customair-dried
出典と根拠
- ORDレコード
- ord-fe0b5de1698444ec8b5a4db7374edae3
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732626B2
反応ノート
読み込み中…