Resorcinol → 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

HRID 15645

反応式

HRID 15645 の反応式
[Cl:1][CH2:2][C:3](=O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:11]1([CH:18]=CC=[C:14](O)[CH:13]=1)[OH:12]>S(=O)(=O)(O)O>[Cl:1][CH2:2][C:3]1[C:9]2[C:8](=[CH:18][C:11]([OH:12])=[CH:13][CH:14]=2)[O:7][C:5](=[O:6])[CH:4]=1

参加物

4

反応物 2

HCID 5054ResorcinolHCID 69484Ethyl 4-chloroacetoacetate

生成物 1

HCID 53988464-(chloromethyl)-7-hydroxy-2H-chromen-2-one収率 84%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.

後処理

  1. temperatureUnder ice-cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customair-dried

出典と根拠

ORDレコード
ord-fe0b5de1698444ec8b5a4db7374edae3
出典データセット
uspto-grants-2010_06
特許番号
US07732626B2

関連ノート

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