3-Bromo-2-methyl-1-benzothiophene → N,N-dimethyl-1-((2-(2-methylbenzo[b]thiophen-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-amine

反応式

[Br:39][c:40]1[c:41]2[c:42]([s:43][c:44]1[CH3:45])[cH:46][cH:47][cH:48][cH:49]2.[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][c:10]2[cH:11][c:12]3[n:13][c:14]([Sn:25]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH2:36][CH3:37])[n:15][c:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[c:17]3[s:18]2)[CH2:7][CH2:8]1)[CH3:38]>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][c:10]2[cH:11][c:12]3[n:13][c:14](-[c:40]4[c:41]5[c:42]([s:43][c:44]4[CH3:45])[cH:46][cH:47][cH:48][cH:49]5)[n:15][c:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[c:17]3[s:18]2)[CH2:7][CH2:8]1)[CH3:38]

参加物

反応物 2

HCID 8218643-Bromo-2-methyl-1-benzothiophene

HCID 59605498Dimethyl-[1-(4-morpholin-4-yl-2-(tributylstannanyl)thieno[3,2-d]pyrimidin-6-ylmethyl)piperidin-4-yl]amine

生成物 1

HCID 49832939N,N-dimethyl-1-((2-(2-methylbenzo[b]thiophen-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-amine

出典と根拠

ORDレコード: ord-8ba5cf1cf20e4166a1be3eba37abf816
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…