1-(3,4-Dichlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → 1-(3,4-Dichlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl) piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide

HRID 1568852

反応式

[Cl:1][c:2]1[cH:3][c:4](-[n:9]2[n:10][cH:11][c:12]([C:15](=[O:16])[OH:17])[c:13]2[CH3:14])[cH:5][cH:6][c:7]1[Cl:8].[NH2:18][c:19]1[cH:20][cH:21][c:22]([N:27]2[CH2:28][CH2:29][N:30]([CH2:33][CH2:34][OH:35])[CH2:31][CH2:32]2)[c:23]([C:24]#[N:25])[cH:26]1>>[Cl:1][c:2]1[cH:3][c:4](-[n:9]2[n:10][cH:11][c:12]([C:15](=[O:17])[NH:18][c:19]3[cH:20][cH:21][c:22]([N:27]4[CH2:28][CH2:29][N:30]([CH2:33][CH2:34][OH:35])[CH2:31][CH2:32]4)[c:23]([C:24]#[N:25])[cH:26]3)[c:13]2[CH3:14])[cH:5][cH:6][c:7]1[Cl:8]