Methane → 4,5-Dihydrotetrazolo[1,5-a]quinoxaline

HRID 1576012ノート

反応式

HRID 1576012 の反応式
[N:1]1[N:5]2[C:6]3[C:11]([N:12]=[CH:13][C:4]2=[N:3][N:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3.C.[H][H]>C(O)C>[N:1]1[N:5]2[C:6]3[C:11]([NH:12][CH2:13][C:4]2=[N:3][N:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3

参加物

5

反応物 3

HCID 297MethaneHCID 10103592HCID 10103592、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 215140494,5-Dihydrotetrazolo[1,5-a]quinoxaline収率 45%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 1 g. portion of tetrazolo[1,5-a]quinoxaline was dissolved in 200 ml. of ethanol. The solution was placed in a Parr hydrogenator on a shaking apparatus and 100 mg. of 5 percent palladized charcoal was added. The bomb was pressurized to about 2 atmospheres with hydrogen and was shaken for 2 hours. The reaction mixture was then removed and filtered. The filtrate was evaporated to dryness and the residue was recrystallized from ethanol-water to obtain the product, 4,5-dihydrotetrazolo[1,5-a]quinoxaline, m.p. 149°-51°C., in 45 percent yield. The product was identified by nuclear magnetic resonance analysis and by elemental microanalysis, with the following results.

後処理

  1. additionwas added
  2. customThe reaction mixture was then removed
  3. filtrationfiltered
  4. customThe filtrate was evaporated to dryness
  5. customthe residue was recrystallized from ethanol-water

出典と根拠

ORDレコード
ord-bd0f956c3b6b459aaedcceb9ea95ca2e
出典データセット
uspto-grants-1976_09
特許番号
US03979387

反応ノート

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