Selenium Dioxide → HCID 178469709、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]2[CH:14]=[N:13][N:12](CC3C=CN=CC=3)[C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2].[Se](=O)=[O:23]>C(O)(=O)C.O>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:23])=[C:8]2[CH:14]=[N:13][NH:12][C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2]参加物
5
実験手順
3 g of 4-hydroxy-1-(4-picolyl-1H-pyrazolo[3,4-b]pyridine- 5-carboxylic acid ethyl ester (0.01 mol) is dissolved in 20 ml of acetic acid, 2.2 g of selenium dioxide (0.02 mol) and 2-3 drops of water are added. The mixture is refluxed for 30 minutes and then filtered off. 4-Hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester precipitates on cooling. Recrystallization from acetic acid yields 1.8 g (87%), m.p. 275°.
後処理
- temperatureThe mixture is refluxed for 30 minutes
- filtrationfiltered off
- custom4-Hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester precipitates
- temperatureon cooling
- customRecrystallization from acetic acid
- customyields 1.8 g (87%), m.p. 275°
出典と根拠
- ORDレコード
- ord-890e0be109b14d0093873c833a9dbd32
- 出典データセット
- uspto-grants-1976_09
- 特許番号
- US03979399
反応ノート
読み込み中…