Hydrochloric Acid → HCID 21500551、化合物

HRID 1576136ノート

反応式

HRID 1576136 の反応式
[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([O:6][C:7]3[CH:8]=[CH:9][C:10]([C:16]([O:18][CH3:19])=[O:17])=[CH:11][C:12]=3[CH2:13]2)=[CH:4][CH:3]=1.ClC(Cl)C.[C:24](Cl)(=[O:26])[CH3:25].[Cl-].[Cl-].[Cl-].[Al+3].Cl>O>[C:24]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:15]=[C:14]2[C:5]=1[O:6][C:7]1[CH:8]=[CH:9][C:10]([C:16]([O:18][CH3:19])=[O:17])=[CH:11][C:12]=1[CH2:13]2)(=[O:26])[CH3:25]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 63651,1-DichloroethaneHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 21500836Methyl 7-methyl-9H-xanthene-2-carboxylate

生成物 1

HCID 21500551HCID 21500551、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 130 g. of methyl 7-methylxanthene-2-carboxylate in 200 ml. of dichloroethane is cooled to -5°C and to the cooled solution are added 4.95 ml. of acetyl chloride and then 17.0 g. of aluminum trichloride. The resultant solution is stirred at room temperature for 1.75 hours. After this time the solution is poured into a mixture of 300 g. of ice, 700 ml. of water and 20 ml. of concentrated hydrochloric acid. The mixture is then extracted with three 500 ml. portions of methylene chloride. The combined extracts are washed with 10% aqueous potassium hydroxide solution and the washed solution evaporated to give methyl 5-acetyl-7-methylxanthene-2-carboxylate.

後処理

  1. additionA mixture of 130 g
  2. additionare added 4.95 ml
  3. additionAfter this time the solution is poured into a mixture of 300 g
  4. extractionThe mixture is then extracted with three 500 ml
  5. washThe combined extracts are washed with 10% aqueous potassium hydroxide solution
  6. customthe washed solution evaporated

出典と根拠

ORDレコード
ord-2f722ca507e44b92ba3a0eece382a852
出典データセット
uspto-grants-1976_09
特許番号
US03979414

反応ノート

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