Dimethylformamide → 4-Bromo-1,1-dimethoxybutane

HRID 1576170ノート

反応式

HRID 1576170 の反応式
[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH2:4][CH2:5][CH2:6]O.CN(C)C=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:35]>O>[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH2:4][CH2:5][CH2:6][Br:35]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 899884,4-Dimethoxybutan-1-ol

生成物 1

HCID 104202254-Bromo-1,1-dimethoxybutane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 0.1 moles of 4,4-dimethoxybutanol in 50 ml. of dimethylformamide containing 0.1 moles of triphenylphosphine is allowed to react for 18 hours with 0.1 moles of carbon tetrabromide. The mixture is diluted with water and extracted with ether. The ether extracts are combined, washed with water, dried and evaporated to a crude product which is purified by distillation to yield 4,4-dimethoxybutylbromide. This bromide is then converted into the diethyl phosphonate using the procedure described in Example 2.

後処理

  1. extractionextracted with ether
  2. washwashed with water
  3. customdried
  4. customevaporated to a crude product which
  5. distillationis purified by distillation

出典と根拠

ORDレコード
ord-2504079ee5c946529545f5211e70f594
出典データセット
uspto-grants-1976_09
特許番号
US03979458

反応ノート

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