Methanol → 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionamide

HRID 1576179ノート

反応式

HRID 1576179 の反応式
C1CO[C:3]2([C:9]3[CH:10]=[CH:11][C:12]([CH:14]([CH3:18])[C:15]([NH2:17])=[O:16])=[CH:13][C:8]=3[CH:7]=[CH:6][C:5]3[CH:19]=[CH:20][CH:21]=[CH:22][C:4]2=3)[O:2]1.CO>O>[CH:13]1[C:8]2[CH:7]=[CH:6][C:5]3[CH:19]=[CH:20][CH:21]=[CH:22][C:4]=3[C:3](=[O:2])[C:9]=2[CH:10]=[CH:11][C:12]=1[CH:14]([CH3:18])[C:15]([NH2:17])=[O:16]

参加物

4

反応物 2

HCID 887MethanolHCID 214030982-(5,5-ethylenedioxy-5H-dibenzo[a,d]cyclohepten-2-yl)propionamide

生成物 1

HCID 214031022-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionamide収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

2.0 Gm. of 2-(5,5-ethylenedioxy-5H-dibenzo[a,d]cyclohepten-2-yl)propionamide is dissolved in 50 ml. of methanol and 5 ml. of N-hydrochloric acid is added. The mixture is heated to 50°C. for 30 minutes then cooled and added to water. The solution is extracted with ethyl acetate and the extract washed, dried and evaporated to yield 80% of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionamide which is recrystallized from methanol, m.p. 158°-159°C. Use of 2-(5,5-ethylenedioxy-5H-dibenzo[a,d]cyclohepten-2-yl)acetamide gives a similar yield of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetamide.

後処理

  1. temperaturethen cooled
  2. extractionThe solution is extracted with ethyl acetate
  3. washthe extract washed
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-44c7603410d44eb9931ec2302e1056b4
出典データセット
uspto-grants-1976_09
特許番号
US03979430

反応ノート

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