Benzene → N-(Ethylcarboethoxy)pyrrole

HRID 1576275ノート

反応式

HRID 1576275 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[K].C(C(Cl)(C)[C:10]([O-:12])=[O:11])C.O.[CH:16]1C=C[CH:19]=[CH:18][CH:17]=1>>[CH2:17]([CH2:18][CH2:19][O:12][C:10]([N:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1)=[O:11])[CH3:16]

参加物

5

反応物 4

HCID 241Benzene2 回HCID 962WaterHCID 19993353EthylchloropropionateHCID 241923201H-Pyrrole, potassium salt (1:1)

生成物 1

HCID 22468057N-(Ethylcarboethoxy)pyrrole

反応条件

温度
80 °C

実験手順

After adding 30 ml of benzene to the potassium pyrrole, a solution of 30.0 g (0.22 mole) of ethylchloropropionate in 30 ml benzene is slowly added to the paste over a period of 1 hour with constant stirring. The reaction mixture is heated to 80°C for 30 minutes. Then 100 ml of water is added and the mixture is extracted with diethyl ether. The ether extract is dried over anhydrous magnesium sulfate and the dried extract is evaporated to yield residue which is distilled under vacuum. The pyrrole derivative having the formula given above is obtained as 3 g of a colorless liquid with a boiling point of 108°C at 14 mm Hg pressure. MS shows the m/e peaks: 80, 94, 167, 27, 95.

後処理

  1. extractionthe mixture is extracted with diethyl ether
  2. extractionThe ether extract
  3. dry with materialis dried over anhydrous magnesium sulfate
  4. extractionthe dried extract
  5. customis evaporated
  6. customto yield residue which
  7. distillationis distilled under vacuum

出典と根拠

ORDレコード
ord-a4d36eedf32440ccaf90c49420657ff3
出典データセット
uspto-grants-1976_09
特許番号
US03980089

反応ノート

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