Hydrochloric Acid → 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3([CH3:20])[CH2:18][C:17](=N)[NH:16][NH:15]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.C([OH:24])C>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3([CH3:20])[CH2:18][C:17](=[O:24])[NH:16][NH:15]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1参加物
4
実験手順
26.9 g of 3-(4'-fluoro-4-biphenylyl)-3-methyl-5-imino-pyrazolidine [obtainable from 3-(4'-fluoro-4-biphenylyl)-2-butenoic acid nitrile and hydrazine] are boiled for 10 minutes with 150 ml of 20% strength aqueous hydrochloric acid and 150 ml of ethanol, and the solution is concentrated, neutralized and worked up in the usual manner to give 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196°.
後処理
- concentrationthe solution is concentrated