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Isovincamine → Vincamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isovincamine | HCID 5668 | — |
| 反応物 | Tetrabutylammonium Hydroxide | HCID 2723671 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Vincamine | HCID 15376 | 36% |
反応手順
If the isomerisation of 16-epivincamine described in Example 4 is repeated but using 177 mg. (0.5 millimole) of 16-epivincamine in 20 ml. of methanol and 130 mg. (0.2 millimole) of a 40% aqueous solution of tetrabutylammonium hydroxide (formula (I)b), and the mixture is allowed to stand for 5 hours at 25°C. 64 mg. of vincamine are obtained (yield 36%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03982002 |
| 出典データセット | uspto-grants-1976_09 |
| ORD ID | ord-9012b34a41504efb94d4b4cd7605aaec |
| 出典メモ | uspto-grants-1976_09 |