化工社化工社 化学情報印刷レポート · 研究参考用
Pyrazole → cis-4,6-Diethyl-5-(4-fluorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazole | HCID 1048 | — |
| 反応物 | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | cis-7,9-Diethyl-1,4-dioxa-8-azaspiro[4.5]decane | HCID 59342374 | — |
| 反応物 | 2,6-Diethyl-1-(4-fluorophenylsulfonyl)piperidin-4-one | HCID 68501988 | — |
| 生成物 | cis-4,6-Diethyl-5-(4-fluorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine | HCID 68499313 | — |
反応手順
Prepared by treatment of 2,6-diethyl-1-(4-fluorophenylsulfonyl)piperidin-4-one, which was prepared by sulfonylation of compound 126 using 4-fluorobenzenesulfonyl chloride followed by deprotection as shown in Example 17, with DMF-DMA followed by pyrazole formation using hydrazine hydrate as shown in Example 15.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732609B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-2b900573df6e4375b11784a30c453654 |
| 出典メモ | uspto-grants-2010_06 |