Hydrochloric Acid → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

HRID 1576777ノート

反応式

HRID 1576777 の反応式
[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:3]1.[ClH:31]>C(O)C>[ClH:31].[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 867340213alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

生成物 1

HCID 867340253alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (104.14 mg., 0.25 mmole) in ethanol (4 ml.) was treated with 0.1N hydrochloric acid (2.5 ml., 0.25 mmole). The solution was evaporated in vacuo and then treated with water (5 ml.). The undissolved solid (8.4 mg.) was removed by filtration and the filtrate was made up to 9.6 ml. with distilled water to give a 1% aqueous solution of the title compound.

後処理

  1. customThe solution was evaporated in vacuo
  2. additiontreated with water (5 ml.)
  3. customThe undissolved solid (8.4 mg.) was removed by filtration

出典と根拠

ORDレコード
ord-740cbae19b3341ea8e4cd3ca7830c7af
出典データセット
uspto-grants-1976_09
特許番号
US03983111

反応ノート

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