Acetic Acid → HCID 86734028、化合物

HRID 1576780ノート

反応式

HRID 1576780 の反応式
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:37])(=[O:36])[CH3:35]>C(O)C>[C:34]([OH:37])(=[O:36])[CH3:35].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 86734023HCID 86734023、化合物

生成物 1

HCID 86734028HCID 86734028、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (116 mg., 0.25 mmole) in ethanol (2 ml.) was treated with 0.1N aqueous acetic acid (2.5 ml. 0.25 mmole) and the resulting solution was evaporated under vacuum. The residue was treated with water (ca 1 ml.) and the undissolved solid (66 mg.) was removed by filtration. The filtrate was diluted to 5 ml. with distilled water, thereby giving a 1% aqueous solution of the title compound.

後処理

  1. customthe resulting solution was evaporated under vacuum
  2. additionThe residue was treated with water (ca 1 ml.)
  3. customthe undissolved solid (66 mg.) was removed by filtration
  4. additionThe filtrate was diluted to 5 ml

出典と根拠

ORDレコード
ord-899a9718125a4c7b83e44bf443dcac5c
出典データセット
uspto-grants-1976_09
特許番号
US03983111

反応ノート

読み込み中…