21-Morpholino-5alpha-pregnane-3,11,20-trione → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

HRID 1576784ノート

反応式

HRID 1576784 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](=[O:30])[C@@H:9]2[C@:26]3([CH3:27])[C@H:12]([C@H:13]4[C@H:23]([C:24](=[O:28])[CH2:25]3)[C@:21]3([CH3:22])[C@H:16]([CH2:17][C:18](=[O:29])[CH2:19][CH2:20]3)[CH2:15][CH2:14]4)[CH2:11][CH2:10]2)[CH2:3][CH2:2]1>O>[OH:29][C@@H:18]1[CH2:19][CH2:20][C@@:21]2([CH3:22])[C@@H:16]([CH2:15][CH2:14][C@@H:13]3[C@@H:23]2[C:24](=[O:28])[CH2:25][C@@:26]2([CH3:27])[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C:8](=[O:30])[CH2:7][N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH2:17]1

参加物

3

反応物 1

HCID 8673403221-Morpholino-5alpha-pregnane-3,11,20-trione

生成物 1

HCID 867340213alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 21-morpholino-5α-pregnane-3,11,20-trione (100 mg.) in the "stock" hloroiridic solution (see preparation 6 below) (10 ml.), was refluxed for 14 hours. The cooled mixture was poured into water and made just alkaline. The slight oily precipitate was extracted into ethyl acetate and the extracts were washed with water, dried (Na2SO4), and evaporated to give essentially the title compound, shown by n.m.r. spectroscopy and T.L.C. (Rf 0.16) on silica in ethyl acetate to be identical to the product of Example 38.

後処理

  1. temperaturewas refluxed for 14 hours
  2. extractionThe slight oily precipitate was extracted into ethyl acetate
  3. washthe extracts were washed with water
  4. dry with materialdried (Na2SO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-6af6eaab32cb46feb5e8f3970243b299
出典データセット
uspto-grants-1976_09
特許番号
US03983111

反応ノート

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