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(1S,2R)-(+)-Norephedrine → alpha-[1-(2-Imidazolin-2-ylamino)ethyl]benzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1S,2R)-(+)-Norephedrine | HCID 4786 | — |
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | alpha-[1-(2-Imidazolin-2-ylamino)ethyl]benzyl alcohol | HCID 54133258 | — |
反応手順
A mixture of 6.5 parts of α-(1-aminoethyl)benzyl alcohol (also known as morephedrine), 5.2 parts of 2-(nitramino)-2-imidazoline and 8 parts of xylene is stirred for 30 minutes while heating at 160°-170°C. The reaction mixture is cooled and diluted with acetone. The latter is removed in vacuo, yielding α-[1-(2-imidazolin-2-ylamino)-ethyl]benzyl alcohol as an oily residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03983133 |
| 出典データセット | uspto-grants-1976_09 |
| ORD ID | ord-7b3aeac0763840eb994f97a3f570e980 |
| 出典メモ | uspto-grants-1976_09 |