関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | alpha-(Aminomethyl)-3,4-dichlorobenzenemethanol | HCID 19349 | — |
| 反応物 | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3,4-Dichloro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol | HCID 54092127 | — |
反応手順
To a stirred solution of 8 parts of α-(aminomethyl)-3,4-dichlorobenzyl alcohol in 4.5 parts of xylene are added 5.2 parts of 2-(nitramino)-2-imidazoline. The whole is heated in an oil-bath at a temperature of about 160°C. till a clear melt is obtained (about 15 minutes). After cooling to about 60°C., the melt is dissolved in acetone and allowed to crystallize. The precipitated product is filtered off and recrystallized from 20 parts of 4-methyl-2-pentanone, yielding 3,4-dichloro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 148°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US03983133 |
|---|
| 出典データセット | uspto-grants-1976_09 |
|---|
| ORD ID | ord-1eff8b94acc348398a5c6955d0e624e0 |
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| 出典メモ | uspto-grants-1976_09 |
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