関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | 2-Amino-1-(4-fluorophenyl)ethan-1-ol | HCID 9827 | — |
| 反応物 | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol | HCID 54097200 | — |
反応手順
To a solution of 6.5 parts of α-(aminomethyl)-p-fluorobenzyl alcohol in 8 parts of xylene are added 5.2 parts of 2-(nitramino)-2-imidazoline. The mixture is heated in an oil-bath to about 160°C. till gas-evolution is ceased (about 15 minutes). The reaction mixture is cooled and treated with benzene and acetone. The product is sucked off and crystallized from 4-methyl-2-pentanone, yielding p-fluoro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 153.4°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US03983133 |
|---|
| 出典データセット | uspto-grants-1976_09 |
|---|
| ORD ID | ord-5e07924bcc1c4a1786b6b7b727016d36 |
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| 出典メモ | uspto-grants-1976_09 |
|---|
