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2-Nitroamino-2-imidazoline → m-Chloro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| 反応物 | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | m-Chloro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol | HCID 54186887 | — |
反応手順
A mixture of 9.5 parts of α-(aminomethyl)-m-chlorobenzyl alcohol, 7.15 parts of 2-(nitramino)-2-imidazoline and 40 parts of xylene is stirred in an oil-bath at 150°-160°C. while a great part of the xylene is distilled off. The resulting residue is diluted with a few parts of acetone and the product is allowed to crystallize. It is filtered off and crystallized from 4-methyl-2-pentanone, yielding m-chloro-α-(2-imidazolin-2-ylaminomethy)benzyl alcohol; m.p. 108.5°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03983133 |
| 出典データセット | uspto-grants-1976_09 |
| ORD ID | ord-b658a509a6ab4b19972339edb308d00a |
| 出典メモ | uspto-grants-1976_09 |