化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 2-Methyl-5-piperazin-1-yl-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylate | HCID 49851900 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Methyl-5-piperazin-1-yl-quinoline | HCID 49851901 | 96% |
反応手順
1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate (D2) (1.1 g) in a 25% solution of trifluoroacetic acid in dichloromethane (10 mL) was stirred at r.t. under an inert atmosphere for 3 hours. The reaction mixture was concentrated under reduced pressure and desalted by means of a 20 g SCX cartridge affording the title compound in 96% yield (0.74 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732600B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-314d2ca9bbee4079b72a99444a2f8f77 |
| 出典メモ | uspto-grants-2010_06 |