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p-Toluenesulfonic acid → Hydroxycitronellal dimethyl acetal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Hydroxycitronellal | HCID 7888 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Methanediol, methoxy- | HCID 5231663 | — |
| 反応物 | 3,7,11-Trimethyl-11-(2-propynyloxy)-2,4-dodecadienoic acid ethyl ester | HCID 53869178 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Hydroxycitronellal dimethyl acetal | HCID 8863 | — |
反応手順
The starting material of Example 1 can be prepared as follows: 172.2 g. of hydroxycitronellal and 106.1 g. of orthoformic acid methyl ester are treated dropwise, while cooling with ice, with a solution of 0.5 g. of p-toluenesulphonic acid in 800 ml. of absolute methanol. After 2 hours, 5 g. of sodium acetate are added and the mixture is concentrated on a rotary evaporator at 50°C. Upon distillation, the residue yields pure 1,1-dimethoxy-3,7-dimethyl-7-octanol; boiling point = 102°C/0.4 mmHg; nD22 = 1.4400.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03983247 |
| 出典データセット | uspto-grants-1976_09 |
| ORD ID | ord-2303cff94e6946bea6d46d04544a1a1c |
| 出典メモ | uspto-grants-1976_09 |