Hydrochloric Acid → AL 321

HRID 1577129ノート

反応式

HRID 1577129 の反応式
[CH3:1][C:2]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH3:21])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([S:18][C:19]#[N:20])[C:13](OCC)=[O:14])=[CH:7][CH:6]=1.Cl.[OH2:29]>C(O)C>[CH3:21][C:2]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([CH3:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]2[S:18][C:19](=[O:29])[NH:20][C:13]2=[O:14])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 12830988HCID 12830988、化合物

生成物 1

HCID 194620AL 321

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.9 g Of ethyl 3-[4-(2-methyl-2-phenylpropyloxy)phenyl]-2-thiocyanatopropionate is dissolved in 20 ml of ethanol and to the solution 20 ml of 6 N--hydrochloric acid is added. The mixture is refluxed for 24 hours. After cooling, water is added to the mixture. The mixture is subjected to extraction with ether. The extract is washed with water and then dried. After distilling off ether, the residue is crystallized from ether-n-hexane, whereby 730 mg of 5-[4-(2-methyl-2-phenylpropyloxy)benzyl]thiazolidine-2,4-dione is obtained.

後処理

  1. temperatureThe mixture is refluxed for 24 hours
  2. temperatureAfter cooling
  3. extractionThe mixture is subjected to extraction with ether
  4. washThe extract is washed with water
  5. customdried
  6. distillationAfter distilling off ether
  7. customthe residue is crystallized from ether-n-hexane

出典と根拠

ORDレコード
ord-678d7033cca44ab1ba57f5206a43aeff
出典データセット
uspto-grants-1981_09
特許番号
US04287200

反応ノート

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