CH2N2Pb → HCID 178433287、化合物

反応式

C[NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])=S.[N:17]#CN.[Pb]>>[CH3:16][C:12]1[N:13]=[CH:14][NH:15][C:11]=1[CH2:10][S:9][CH2:8][CH2:7][CH2:6][NH:5][C:3](=[NH:17])[NH2:2]

参加物

反応物 2

HCID 22262466CH2N2Pb

HCID 178486113HCID 178486113、化合物

生成物 1

HCID 178433287HCID 178433287、化合物収率 17.5%

実験手順

The reaction of N-methyl-N'-[3-((4-methyl-5-imidazolyl)methylthio)propyl]thiourea (5.9 g.) with lead cyanamide (17.5 g.) by a procedure similar to that described in Example 3(b) afforded N-cyano-N'-methyl-N"-[3-((4-methyl-5-imidazolyl)methylthiopropyl]guanidine (0.91 g.), m.p. 156°-158°, following chromatography on silica gel with successive elution by chloroformethyl acetate (1:1), ethyl acetate and ethyl acetate isopropyl alcohol (5:1) and final recrystallisation from isopropyl alcohol-ether. (Found: C, 49.5; H, 7.0; S, 12.0. C11H18N6S requires: C, 49.6; H, 6.8; S, 12.0).

出典と根拠

ORDレコード: ord-280250d1ae90493cb2078b4ac3019b41
出典データセット: uspto-grants-1981_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04287198

反応ノート

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