5-chloro-2,2-dimethylpentanenitrile → 3,4,5,6-Tetrahydro-2,3,3-trimethylpyridine

HRID 1577291ノート

反応式

HRID 1577291 の反応式
[CH3:1][Li].Cl[CH2:4][CH2:5][CH2:6][C:7]([CH3:11])([CH3:10])[C:8]#[N:9]>CCOCC>[CH3:1][C:8]1[C:7]([CH3:11])([CH3:10])[CH2:6][CH2:5][CH2:4][N:9]=1

参加物

4

反応物 2

HCID 2642175-chloro-2,2-dimethylpentanenitrileHCID 178418348HCID 178418348、化合物

生成物 1

HCID 131577763,4,5,6-Tetrahydro-2,3,3-trimethylpyridine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

0.1 mol of methyl lithium dissolved in 200 ml of ether anhydride is added drop by drop in an inert atmosphere (argon or nitrogen) to 15 g of 5-chloro-2,2-dimethyl pentane nitrile diluted in 60 ml of anhydrous ether. The reaction mixture is maintained between 0° and 5° C. during the addition and then for a further 30 minutes and then kept at room temperature for 4 hours. After hydrolysis it is extracted with ether. The 2,3,3-trimethyl-3,4,5,6-tetrahydropyridine is then isolated by distillation. A colorless liquid of B.P.14 =60° C. is obtained in a yield of 76% of 1-piperideine.

後処理

  1. temperatureThe reaction mixture is maintained between 0° and 5° C. during the addition
  2. waitkept at room temperature for 4 hours
  3. customAfter hydrolysis it
  4. extractionis extracted with ether

出典と根拠

ORDレコード
ord-5cf60033b1114b4991f12c32ea544805
出典データセット
uspto-grants-1981_09
特許番号
US04287337

反応ノート

読み込み中…