Acetyl chloride → N-(2,4,5-Trichlorophenyl)acetamide
反応式
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:12]=[C:11]([Cl:13])[C:10]([Cl:14])=[CH:9][C:7]=1[NH2:8]>ClCCl>[CH3:2][C:1]([NH:8][C:7]1[C:6]([Cl:5])=[CH:12][C:11]([Cl:13])=[C:10]([Cl:14])[CH:9]=1)=[O:3]参加物
4
反応条件
- 温度
- 50 °C
実験手順
Acetyl chloride (2.13 mls; 0.03 mole) is added dropwise to a suspension of 2,4,5-trichloroaniline (4.91 g; 0.025 mole) and powdered 3A molecular sieves (7.4 g) in dichloromethane (25 mls), at room temperature, under a nitrogen atmosphere. When addition is completed, the mixture is heated to 50° C. for 1.5 hours and then cooled to room temperature. The 3A sieves are separated by filtration and washed with dichloromethane. All dichloromethane solutions are combined and evaporated to obtain 4.1 grams (69% of theoretical) of the solid product; m.p. 188°-190° C. after recrystallized from toluene.