Benzylamine → 75484-74-1

HRID 1577801ノート

反応式

HRID 1577801 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[C:3]=1[N+:10]([O-:12])=[O:11].[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)(C)C>[ClH:1].[CH2:13]([NH:20][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[C:3]=1[N+:10]([O-:12])=[O:11])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 107027254-Chloro-2,6-dimethyl-3-nitropyridine

生成物 1

HCID 2056958975484-74-1

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

9.3 Grams (0.05 mol) of 4-chloro-2,6-dimethyl-3-nitropyridine and 10.7 g (0.1 mol) of benzylamine are heated for 5 hours at boiling point in 20 ml of isopropanol. After cooling, the mixture is concentrated, dissolved in water and extracted with chloroform. The chloroform phase is dried with sodium sulfate and concentrated. The residue is converted with ethanolic hydrochloric acid into the hydrochloride and recrystallized from isopropanol.

後処理

  1. temperatureAfter cooling
  2. concentrationthe mixture is concentrated
  3. dissolutiondissolved in water
  4. extractionextracted with chloroform
  5. dry with materialThe chloroform phase is dried with sodium sulfate
  6. concentrationconcentrated
  7. customrecrystallized from isopropanol

出典と根拠

ORDレコード
ord-29a122e524ff4855ad8c54d9ee8de13d
出典データセット
uspto-grants-1981_09
特許番号
US04289765

反応ノート

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