Hydrochloric Acid → 5-(4-Chlorophenyl)pyrimidin-2(1H)-one
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH:11]N(C)C)[CH:9]=O)=[CH:4][CH:3]=1.[NH2:15][C:16]([NH2:18])=[O:17].Cl.[Cl-].[NH4+]>C(O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:11]=[N:15][C:16](=[O:17])[NH:18][CH:9]=2)=[CH:4][CH:3]=1参加物
7
実験手順
A mixture of 2-(4-chlorophenyl)dimethylaminopropenal (Example 145a) (5.13 g), urea (2.4 g), concentrated HCl (10 ml), water (4 ml) and ethanol (150 ml) was refluxed for 4 hours. After cooling to room temperature concentrated ammonium chloride was added until the pH was 7. The resulting yellow solid was filtered off and dried yielding 1.5 g of 5-(4-chlorophenyl)-2-pyrimidinone.
後処理
- temperaturewas refluxed for 4 hours
- additionwas added until the pH was 7
- filtrationThe resulting yellow solid was filtered off
- customdried
出典と根拠
- ORDレコード
- ord-50a47b176604482395560ff8f1a4f880
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726176
反応ノート
読み込み中…