Hydrochloric Acid → 4H-Pyrido(1,2-a)pyrimidin-4-one, 7-chloro-3-ethyl-2-methyl-, monohydrochloride

HRID 1578095ノート

反応式

HRID 1578095 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:5]2[C:6](=[O:10])[C:7]=1[CH2:8][CH3:9].Cl>C(O)C>[ClH:15].[CH3:1][C:2]1[N:3]=[C:4]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:5]2[C:6](=[O:10])[C:7]=1[CH2:8][CH3:9]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 3053807HCID 3053807、化合物

生成物 1

HCID 30538064H-Pyrido(1,2-a)pyrimidin-4-one, 7-chloro-3-ethyl-2-methyl-, monohydrochloride収率 97%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

4.45 g. of 2-methyl-3-ethyl-7-chloro-4-oxo-4H-pyrido[1,2-a]-pyrimidine are dissolved in ethanol, with heating, then 25 ml. of a 28% by weight solution of hydrogen chloride in ethanol is added to the solution obtained. The precipitated crystals are filtered off and washed with ethanol. 5.01 g. (97%) of 2-methyl-3-ethyl-7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine hydrochloride are obtained, M.P. 176° to 180° C.

後処理

  1. temperaturewith heating
  2. customobtained
  3. filtrationThe precipitated crystals are filtered off
  4. washwashed with ethanol

出典と根拠

ORDレコード
ord-8bb81b3020ef453e9fa147ec43ea78da
出典データセット
uspto-grants-1981_09
特許番号
US04291036

反応ノート

読み込み中…