Acetylthioacetylchloride → (2S)-1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid

反応式

[C:1]([N:11]1[CH2:18][C:17]([CH2:20][C:21]2[O:22][CH:23]=[CH:24][CH:25]=2)(O)[CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])([O:3]CC1C=CC=CC=1)=O.C(CC(Cl)=S)(=O)C.[C:33]([S:36][C:37]1(C(O)=O)C(C(=O)C)=CCN1CC1OC=CC=1)(=[O:35])[CH3:34]>>[C:33]([S:36][CH2:37][C:1]([N:11]1[CH2:18][C:17]([CH2:20][C:21]2[O:22][CH:23]=[CH:24][CH:25]=2)=[CH:16][C@H:12]1[C:13]([OH:15])=[O:14])=[O:3])(=[O:35])[CH3:34]

参加物

反応物 3

HCID 23301560Acetylthioacetylchloride

HCID 54161613N-carbobenzyloxy-4-[(2-furyl)methyl]-4-hydroxy-L-proline

HCID 867380162-(Acetylthio)-1-oxoethyl-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid

生成物 1

HCID 57078237(2S)-1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid

実験手順

4-[(2-Furyl)methyl]-3,4-dehydro-L-proline from part (a) is reacted with 2-acetylthioacetyl chloride according to the procedure of Example 3 (b) to yield (2S)-1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-2,5-dihydro-1H-pyrrole-2-carboxylic acid.

出典と根拠

ORDレコード: ord-ff8f2af28dbe4ecebcab9524204cd294
出典データセット: uspto-grants-1981_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04291040

反応ノート

読み込み中…