1-(Cyclopent-1-en-1-yl)-3-methoxybenzene → HCID 20499284、化合物

HRID 1578155ノート

反応式

HRID 1578155 の反応式
O.O.O.C([O-])(=[O:6])C.[Na+].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:17]2[CH2:21][CH2:20][CH2:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1>C(OO)(=O)C.ClCCl>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:17]23[O:6][CH:21]2[CH2:20][CH2:19][CH2:18]3)[CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 2

HCID 2724811-(Cyclopent-1-en-1-yl)-3-methoxybenzeneHCID 23665404Sodium Acetate Trihydrate

生成物 1

HCID 20499284HCID 20499284、化合物収率 298%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6585Peracetic Acid溶媒

実験手順

A solution of sodium acetate trihydrate (6 g) in peracetic acid (38 ml) was added dropwise to a stirred solution of 1-(3-methoxyphenyl) cyclopentene (33.5 g) in dichloromethane (200 ml), maintaining the temperature in the range 0°-10°. The solution was stirred for 3 hours at room temperature and then washed with 8% aqueous sodium bicarbonate (700 ml) and 8% sodium thiosulphate solution (400 ml). The organic phase was separated, dried and evaporated and the residue was distilled in vacuo to give the title compound as a colourless oil (25 g) b.p. 89°-92° (0.01 mm).

後処理

  1. temperaturemaintaining the temperature in the range 0°-10°
  2. washwashed with 8% aqueous sodium bicarbonate (700 ml) and 8% sodium thiosulphate solution (400 ml)
  3. customThe organic phase was separated
  4. customdried
  5. customevaporated
  6. distillationthe residue was distilled in vacuo

出典と根拠

ORDレコード
ord-0f2e9478bf6445c1baf6d0eec77f9d60
出典データセット
uspto-grants-1981_09
特許番号
US04291059

反応ノート

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