Morpholine → 4-Isopropylamino-2-morpholino-thieno[3,4-d]pyrimidine

HRID 1579424ノート

反応式

HRID 1579424 の反応式
Cl[C:2]1[N:3]=[C:4]([NH:11][CH:12]([CH3:14])[CH3:13])[C:5]2[C:6](=[CH:8][S:9][CH:10]=2)[N:7]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>O>[CH:12]([NH:11][C:4]1[C:5]2[C:6](=[CH:8][S:9][CH:10]=2)[N:7]=[C:2]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:3]=1)([CH3:14])[CH3:13]

参加物

4

反応物 2

HCID 8083MorpholineHCID 215684292-Chloro-4-isopropylamino-thieno[3,4-d]pyrimidine

生成物 1

HCID 215684624-Isopropylamino-2-morpholino-thieno[3,4-d]pyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

6 g (0.26 moles) of 2-chloro-4-isopropylamino-thieno[3,4-d]pyrimidine and 25 mls. of morpholine are mixed and then heated under reflux for 4 hours. The mixture is cooled and poured into water with vigorous agitation; a brown solid appears, which is separated by filtration, washed with water and put to dry. The product is converted into the maleate, which is recrystallized from acetone. The free base is obtained again by treatment with alkali and is this way one obtains 3.4 g of pure product. M.P. 202°C. with decomposition.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. temperatureThe mixture is cooled
  4. customa brown solid appears, which is separated by filtration
  5. washwashed with water
  6. customto dry
  7. customis recrystallized from acetone
  8. customThe free base is obtained again by treatment with alkali and

出典と根拠

ORDレコード
ord-685980e4ef7b491d939a9d7691cb4c6f
出典データセット
uspto-grants-1976_01
特許番号
US03931204

反応ノート

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