Propylamine → 2-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

HRID 1579427ノート

反応式

HRID 1579427 の反応式
[CH2:1]([O:3][C:4]1[N:5]=[C:6](OCC)[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2].[CH2:16]([NH2:19])[CH2:17][CH3:18]>C(O)C>[CH2:1]([O:3][C:4]1[N:5]=[C:6]([NH:19][CH2:16][CH2:17][CH3:18])[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2]

参加物

4

反応物 2

HCID 7852PropylamineHCID 21568428HCID 21568428、化合物

生成物 1

HCID 215684642-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2.3 g (0.01 mole) of 2,4-diethoxy-thieno[3,4-d]pyrimidine and 3.6 g (0.06 mole) of n-propylamine in 50 ml absolute ethyl alcohol is heated under reflux for 10 hours. The solution is then evaporated to dryness. The solid is drained off, washed with water and dried. After recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine are obtained. M.P. 140°-142°C.

後処理

  1. temperatureunder reflux for 10 hours
  2. customThe solution is then evaporated to dryness
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine
  6. customare obtained

出典と根拠

ORDレコード
ord-98122460a0e44fd8860c40a40c6481f6
出典データセット
uspto-grants-1976_01
特許番号
US03931204

反応ノート

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