Diethyl Oxalate → HCID 21509105、化合物

HRID 1579465ノート

反応式

HRID 1579465 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:13][C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2].[C:16](OCC)(=[O:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>[O-]CC.[Na+]>[C:14]([CH:13]([C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH3:12])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=1)[C:16](=[O:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])#[N:15]

参加物

4

反応物 2

HCID 7268Diethyl OxalateHCID 520318(3,4-Diethoxyphenyl)acetonitrile

生成物 1

HCID 21509105HCID 21509105、化合物

試薬・触媒・溶媒 1

HCID 2723922Sodium ethoxide溶媒

実験手順

By following the procedures outlined in Examples 1 and 3, 3,4-diethoxyphenylacetonitrile is reacted with diethyl oxalate in alcoholic sodium ethoxide solution to give ethyl 3-cyano-3-(3',4'-diethoxyphenyl)pyruvate. This compound is similarly reacted with 3,4-diethoxyphenylacetonitrile which results in the formation of 2,5-di-(3',4'-diethoxyphenyl)-3,4-dioxoadiponitrile. The latter is refluxed with water, acetic acid and sulfuric acid to give 3,4,3',4'-tetraethoxypulvinic acid which is treated with acetic anhydride to give the corresponding acid lactone.

出典と根拠

ORDレコード
ord-db3b1a8db8924f7ab76b65cc2f002e30
出典データセット
uspto-grants-1976_01
特許番号
US03931207

反応ノート

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