Acetic Anhydride → HCID 21568996、化合物

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([CH3:15])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([CH3:15])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)(=[O:18])[CH3:17]

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 2302841HCID 2302841、化合物

生成物 1

HCID 21568996HCID 21568996、化合物収率 73%

実験手順

A mixture of 5.0 g (0.0248 mole) of methyl 5-(p-aminophenyl)-2-furyl ketone and 75 ml of acetic anhydride was heated at 70°-90° for 2 hours. The excess acetic anhydride was removed on a Calab evaporator, and the residual solid was recrystallized from ethyl acetate to yield 4.4 g (73%) of methyl 5-(p-acetamidophenyl)-2-furyl ketone. An analytical sample was prepared by drying a sample in the vacuum pistol at the temperature of refluxing chloroform, m.p. 214°-215°.

後処理

temperaturewas heated at 70°-90° for 2 hours
customThe excess acetic anhydride was removed on a Calab evaporator
customthe residual solid was recrystallized from ethyl acetate

出典と根拠

ORDレコード: ord-aebf2f57fee44aed899eceb7169c3f6d
出典データセット: uspto-grants-1976_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03931247

反応ノート

読み込み中…

参加物