Water → 3-(3'-Cyano-2'-hydroxypropyl)-benzophenone

HRID 1579774

反応式

HRID 1579774 の反応式
[C:1]([CH2:3][CH:4]([OH:20])[CH2:5][C:6]1[CH:7]=[C:8]([CH:17]=[CH:18][CH:19]=1)[CH:9]([OH:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)#[N:2].O>CC(C)=O>[C:1]([CH2:3][CH:4]([OH:20])[CH2:5][C:6]1[CH:7]=[C:8]([CH:17]=[CH:18][CH:19]=1)[C:9]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:16])#[N:2]

参加物

4

反応物 2

HCID 962WaterHCID 214956743-(3'-Cyano-2'-hydroxypropyl)-benzhydrol

生成物 1

HCID 214956823-(3'-Cyano-2'-hydroxypropyl)-benzophenone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

7.35 ml of a sulfochromic mixture titrating 26.5 g of chromic anhydride per 100 ml was added with stirring at 0°C to 7.8 g of 3-(3'-cyano-2'-hydroxypropyl)-benzhydrol in 78 ml of acetone and the mixture was allowed to stand at 0°C for 5 minutes and was then poured into water with stirring. The mixture was extracted with methylene chloride and the organic phase was washed with water, dried over sodium sulfate, treated with activated carbon, filtered and evaporated to dryness to obtain 7.4 g of 3-(3'-cyano-2'-hydroxypropyl)-benzophenone which was used as is for the next step.

後処理

  1. additionwas added
  2. extractionThe mixture was extracted with methylene chloride
  3. washthe organic phase was washed with water
  4. dry with materialdried over sodium sulfate
  5. additiontreated with activated carbon
  6. filtrationfiltered
  7. customevaporated to dryness

出典と根拠

ORDレコード
ord-6660c3a01fc6444ea4cf5686726f441b
出典データセット
uspto-grants-1976_01
特許番号
US03931302

関連ノート

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