Dimethylformamide → HCID 18594803、化合物

HRID 1580231ノート

反応式

HRID 1580231 の反応式
CS(O[CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1)(=O)=O.CN(C)C=O.[Cl-:36].[Li+]>O>[Cl:36][CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 433294Lithium ChlorideHCID 18594876HCID 18594876、化合物

生成物 1

HCID 18594803HCID 18594803、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.35 g. of ethyl 15-methanesulfonyloxy 9-oxo-prostanoate (Example 90) in 40 ml. of N,N-dimethylformamide containing 650 mg. of lithium chloride is heated on the steam bath for 18 hours. The cooled solution is diluted with water and the resulting mixture is extracted with ether. The ether extract is washed with saline, dried with saline, dried with anhydrous magnesium sulfate and evaporated to dryness to give an oil. Chromatography on silica gel affords an oil; λmax. 5.78 μ (carbonyl groups).

後処理

  1. extractionthe resulting mixture is extracted with ether
  2. extractionThe ether extract
  3. washis washed with saline
  4. customdried with saline
  5. dry with materialdried with anhydrous magnesium sulfate
  6. customevaporated to dryness
  7. customto give an oil
  8. customChromatography on silica gel affords an oil

出典と根拠

ORDレコード
ord-11bb2503511e402c905725720c09bf80
出典データセット
uspto-grants-1976_01
特許番号
US03932472

反応ノート

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