Acetone → HCID 18594874、化合物

HRID 1580233ノート

反応式

HRID 1580233 の反応式
CS(O[CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1)(=O)=O.[CH3:31][C:32](C)=[O:33].[S:35]1C=CC=C1CC([O-])=O.[K+]>O>[C:32]([S:35][CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1)(=[O:33])[CH3:31]

参加物

5

反応物 3

HCID 180AcetoneHCID 18594876HCID 18594876、化合物HCID 23696799Potassium 2-thienylacetate

生成物 1

HCID 18594874HCID 18594874、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1 g. of ethyl 15-methanesulfonyloxy-9-oxo-prostanoate (Example 90) in 50 ml. of acetone containing 735 mg. of purified potassium thiolacetate is kept at the reflux temperature for 2 hours, then at room temperature for 18 hours. The mixture is diluted with water and the resulting solution is washed with saturated sodium chloride solution, dried with magnesium sulfate and taken to dryness. The residue is chromatographed on silica gel to give an oil; λmax. 5.78 (ring carbonyl and ester group) and 5.92 μ (acetylthio group).

後処理

  1. washthe resulting solution is washed with saturated sodium chloride solution
  2. dry with materialdried with magnesium sulfate
  3. customThe residue is chromatographed on silica gel
  4. customto give an oil

出典と根拠

ORDレコード
ord-b9b8a974cc4741b7a1803036e3f2b74b
出典データセット
uspto-grants-1976_01
特許番号
US03932472

反応ノート

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