Sodium Methoxide → HCID 18594804、化合物

HRID 1580235ノート

反応式

HRID 1580235 の反応式
C([S:4][CH:5]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:6][CH2:7][C@@H:8]1[C@@H:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:11](=[O:24])[CH2:10][CH2:9]1)(=O)C.C[O-].[Na+]>CO>[O:24]=[C:11]1[CH2:10][CH2:9][C@H:8]([CH2:7][CH2:6][CH:5]([SH:4])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 18594874HCID 18594874、化合物

生成物 1

HCID 18594804HCID 18594804、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 606 mg. of ethyl 15-acetylthio-9-oxoprostanoate (Example 113) in 20 ml. of reagent methanol is treated, under nitrogen atmosphere, with 1.6 ml. of 1N methanolic sodium methoxide. After 10 minutes the reaction is quenched by the addition of 0.3 ml. of glacial acetic acid and taken to dryness. A solution of the residue in ether is washed with saturated sodium chloride solution, dried with anhydrous magnesium sulfate and taken to dryness to afford 428 mg. (89%) of an oil; λmax. 4.0 (sulfhydryl) and 5.78 μ (carbonyls).

後処理

  1. customAfter 10 minutes the reaction is quenched by the addition of 0.3 ml
  2. washA solution of the residue in ether is washed with saturated sodium chloride solution
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customto afford 428 mg

出典と根拠

ORDレコード
ord-9b63541ab430480fb40b028b798140fe
出典データセット
uspto-grants-1976_01
特許番号
US03932472

反応ノート

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