Water → N'-(4-chlorocyclohexyl)-urea

HRID 1580321ノート

反応式

HRID 1580321 の反応式
C1(S([N:10](C)[C:11](OCC)=[O:12])(=O)=O)C=CC=CC=1.[Cl:17][CH:18]1[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]1.C([O-])(=O)C.O.CO.CN(C)C=O>O1CCOCC1>[Cl:17][CH:18]1[CH2:23][CH2:22][CH:21]([NH:24][C:11](=[O:12])[NH2:10])[CH2:20][CH2:19]1

参加物

6

反応物 4

HCID 962WaterHCID 21901440N,N-dimethylformamide methanolHCID 53724984Benzenesulfonyl-methyl-urethaneHCID 867329474-Chlorocyclohexylamine acetate

生成物 1

HCID 86732946N'-(4-chlorocyclohexyl)-urea

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4.26 g of N-[4-(β-<2-methoxy-5-chlorobenzamido>-ethyl)-benzenesulfonyl-methyl-urethane are heated for 1 1/2 hours in a reflux condenser in 100 ml dioxane with 2 g of 4-chlorocyclohexylamine-acetate. After addition of water and recrystallization of the precipitating product from methanol/dimethylformamide there is obtained in good yield the N-[4-<2-methoxy-5-chlorobenzamido>-ethyl)-benzenesulfonyl]-N'-(4-chlorocyclohexyl)-urea melting at 177° -178°C.

後処理

  1. customis obtained

出典と根拠

ORDレコード
ord-af9cfbca12b34e2da601f7fc3c514af1
出典データセット
uspto-grants-1976_01
特許番号
US03932503

反応ノート

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