3-Amino-1-propanol → 1-(2,4-Dimethylphenyl)-3-(3-hydroxypropyl)thiourea

HRID 1580631ノート

反応式

HRID 1580631 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[OH:12][CH2:13][CH2:14][CH2:15][NH2:16]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH:16][CH2:15][CH2:14][CH2:13][OH:12])=[S:11]

参加物

4

反応物 2

HCID 90863-Amino-1-propanolHCID 1423861-Isothiocyanato-2,4-dimethylbenzene

生成物 1

HCID 21711911-(2,4-Dimethylphenyl)-3-(3-hydroxypropyl)thiourea

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

A solution of 2,4-dimethylphenylisothiocyanate in about 70 ml. of benzene was added dropwise to an agitated solution of 3-hydroxypropylamine (3.8 grams) in about 80 ml. of benzene. The resulting reaction mixture was maintained, with stirring, at ambient temperatures for about 16 hours. Following such period, the benzene in the reaction mixture was removed in vacuo and the residual oil triturated with ethyl ether and the desired product crystallized therefrom and washed again with ethyl ether. As a result of such operations, the desired N-(2,4-dimethylphenyl)-N'-(3-hydroxypropyl)-thiourea product was obtained as a white solid having a melting point of 90° - 93°C.

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas maintained
  3. waitFollowing such period
  4. customthe benzene in the reaction mixture was removed in vacuo
  5. customthe residual oil triturated with ethyl ether
  6. customthe desired product crystallized
  7. washwashed again with ethyl ether
  8. customAs a result of such operations

出典と根拠

ORDレコード
ord-94561180df864c719153891f18af9760
出典データセット
uspto-grants-1976_01
特許番号
US03933833

反応ノート

読み込み中…