Benzoyl chloride → 2-(2'-Fluorophenoxy)-6-isothiocyanobenzothiazole

HRID 1580682ノート

反応式

HRID 1580682 の反応式
[C:1]([SH:3])#N.N.C(Cl)(=O)C1C=CC=CC=1.[F:14][C:15]1[CH:31]=[CH:30][CH:29]=[CH:28][C:16]=1[O:17][C:18]1[S:19][C:20]2[CH:26]=[C:25]([NH2:27])[CH:24]=[CH:23][C:21]=2[N:22]=1>CC(C)=O>[F:14][C:15]1[CH:31]=[CH:30][CH:29]=[CH:28][C:16]=1[O:17][C:18]1[S:19][C:20]2[CH:26]=[C:25]([N:27]=[C:1]=[S:3])[CH:24]=[CH:23][C:21]=2[N:22]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 13417437AmthioHCID 21563674HCID 21563674、化合物

生成物 1

HCID 215636782-(2'-Fluorophenoxy)-6-isothiocyanobenzothiazole

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

An amount of 17 g of ammonium rhodanide is dissolved in 200 ml of absolute acetone; an addition is then made to the solution, with stirring, of 31 g of benzoyl chloride. The reaction mixture is allowed to boil with refluxing for 5 minutes; a solution is then added of 57 g of 2-(2'-fluorophenoxy)-6-aminobenzothiazole (obtained from 2-(2'-fluorophenoxy)-6-nitrobenzothiazole by catalytic hydrogenation, cp. Example 6) in 400 ml of acetone. Stirring is continued for 2 minutes at the boiling temperature, and the mixture then poured, with stirring, into 5000 ml of ice water. Filtration is performed, the filter residue washed with water, and suspended in 350 ml of 10% sodium hydroxide solution. The suspension is quickly brought to boiling temperature and allowed to boil for a further 2 minutes. Cooling is then rapidly carried out in an ice bath; the suspension is neutralised with 2-n hydrochloric acid, and the pH-value adjusted with 2-n ammonia to 8. Filtration is again performed, the filter residue washed wth water until neutral, and dried at 80° in vacuo. The finely powdered material is suspended in 500 ml of anhydrous chlorobenzene and refluxed for 14 hours. After the solvent has been evaporated off, the residue is chromatographed through aluminium oxide with methylene chloride as the eluant. The obtained 2-(2'-fluorophenoxy)-6-isothiocyanobenzothiazole melts at 115° - 117°.

後処理

  1. additionan addition
  2. temperaturewith refluxing for 5 minutes
  3. additionthe mixture then poured
  4. filtrationFiltration
  5. washthe filter residue washed with water
  6. waitto boil for a further 2 minutes
  7. temperatureCooling
  8. customis then rapidly carried out in an ice bath
  9. filtrationFiltration
  10. washthe filter residue washed wth water until neutral, and
  11. customdried at 80° in vacuo
  12. temperaturerefluxed for 14 hours
  13. customAfter the solvent has been evaporated off
  14. customthe residue is chromatographed through aluminium oxide with methylene chloride as the eluant

出典と根拠

ORDレコード
ord-bf2d2a1a2df24c928b8bfe62cb043eab
出典データセット
uspto-grants-1976_01
特許番号
US03933841

反応ノート

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