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3',4',5'-Trimethoxyacetophenone → 3,9-Dimethyl-2-[2-methyl-2-(3,4,5-trimethoxyphenyl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3',4',5'-Trimethoxyacetophenone | HCID 14345 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | 2,3,9-Trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 12339719 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3,9-Dimethyl-2-[2-methyl-2-(3,4,5-trimethoxyphenyl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-4-one | HCID 56638083 | — |
反応手順
To a solution of 1.3g of sodium methoxide in 75 ml of absolute methanol is added 2.0g of 2,3,9-trimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, followed by 4.2g of 3,4,5-trimethoxyacetophenone. The mixture is stirred and heated under reflux for 97 hours to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03935197 |
| 出典データセット | uspto-grants-1976_01 |
| ORD ID | ord-3b46f4bd6cd34af7aedd772a6e636d2e |
| 出典メモ | uspto-grants-1976_01 |