Ammonia → 5-(3,4-Dibromobutyl)pyridine-2-carboxamide

HRID 1580973

反応式

HRID 1580973 の反応式
[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11](O)=[O:12])=[N:9][CH:10]=1.[NH3:16]>C(O)C.Cl>[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH2:16])=[O:12])=[N:9][CH:10]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 2167205-(3,4-Dibromobutyl)pyridine-2-carboxylic acid

生成物 1

HCID 132718775-(3,4-Dibromobutyl)pyridine-2-carboxamide

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒2 回

実験手順

10 g of 5-(3,4-dibromobutyl)picolinic acid was dissolved in 200 ml of ethanol saturated with dry hydrochloride gas and resulting solution was refluxed for six hours. Reaction mixture was evaporated in reduced pressure and resulting pale yellow oil was dissolved in 300 ml of ethanol saturated with dry ammonia gas. The solution was kept to stand at room temperature for three days, and then evaporated in reduced pressure. Resulting solid was crystallized from benzene to give 6.5 g of the pure product as platelets.

後処理

  1. customresulting solution
  2. temperaturewas refluxed for six hours
  3. customReaction mixture
  4. customwas evaporated in reduced pressure
  5. customresulting pale yellow oil
  6. customevaporated in reduced pressure
  7. customResulting solid
  8. customwas crystallized from benzene

出典と根拠

ORDレコード
ord-dcd86b428b6948b8a5f064103ab4adad
出典データセット
uspto-grants-1976_01
特許番号
US03935221

関連ノート

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