Acetic Acid → 5-Methyl-7-(3-nitrophenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid 6-methyl ester 8-ethyl ester
反応式
CO[C:3](=O)[CH2:4][C:5]([CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)=O.[C:19]([CH:24]=[C:25]1[CH2:29]C[CH2:27][NH:26]1)([O:21][CH2:22]C)=[O:20].[CH2:30]([OH:32])[CH3:31].[C:33](O)(=[O:35])C>>[CH2:30]([O:32][C:33]([C:7]1[CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=2)[C:24]([C:19]([O:21][CH3:22])=[O:20])=[C:25]([CH3:29])[N:26]2[C:5]=1[CH2:4][CH2:3][CH2:27]2)=[O:35])[CH3:31]参加物
5
実験手順
Upon boiling a solution of 8.3 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 5.6 g of 2-carbethoxymethylidenepyrrolidine in 50 ml of glacial acetic acid for 8 hours, 5-methyl-7-(3-nitrophenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid 6-methyl ester 8-ethyl ester of melting point 120° (ethanol) is obtained.