Isopropanol → 6-(3-Trifluoromethyl-benzenesulfonyl)-2H-pyridazin-3-one
反応式
Cl[C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[Na+].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]([S:18]([O-:20])=[O:19])[CH:15]=[CH:16][CH:17]=1.C([OH:26])(C)C>O>[F:22][C:11]([F:10])([F:21])[C:12]1[CH:13]=[C:14]([S:18]([C:2]2[CH:7]=[CH:6][C:5](=[O:26])[NH:4][N:3]=2)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1参加物
5
実験手順
A mixture of 3,6-dichloropyridazine (4.44 g), 3-trifluoromethylphenyl sulfinic acid sodium salt (6.93 g), isopropanol (30 mL), and water (1 mL) was prepared and refluxed for 18 hours. The reaction mixture was then cooled, diluted with water (100 mL) and the precipitated solid was collected. The solid was triturated with n-propanol and the solid was collected to obtain the title compound (25%, 2.3 g).