Potassium Carbonate → HCID 22506953、化合物

HRID 1581485ノート

反応式

HRID 1581485 の反応式
[F:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[SH:9].Cl[N:11]1[CH:16]=[CH:15][CH:14]=[C:13](Cl)[NH:12]1.[C:18](=O)([O-])[O-:19].[K+].[K+]>CC(C)=O>[Br:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][C:16]2[N:11]=[N:12][C:13]([O:19][CH3:18])=[CH:14][CH:15]=2)=[C:2]([F:1])[CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 22028949HCID 22028949、化合物HCID 225069554-Bromo-2-fluorobenzene-1-thiol

生成物 1

HCID 22506953HCID 22506953、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-fluoro-4-bromothiophenol (300 mg), 2,6-dichloro-pyridazine (149 mg), potassium carbonate (400 mg) and acetone (6 mL) was prepared and refluxed for two hours. The acetone from the mixture was evaporated and the resulting residue was dissolved in a solution of methanol (3 mL) and sodium metal (166 mg). The resulting solution was refluxed for 1 hour. Evaporation of methanol afforded 3-(4-bromo-2-fluoro-phenylsulfanyl)-6-methoxy-pyridazine, which was not isolated but was immediately used in Step 2.

後処理

  1. customwas prepared
  2. temperaturerefluxed for two hours
  3. customThe acetone from the mixture was evaporated
  4. dissolutionthe resulting residue was dissolved in a solution of methanol (3 mL) and sodium metal (166 mg)
  5. temperatureThe resulting solution was refluxed for 1 hour
  6. customEvaporation of methanol

出典と根拠

ORDレコード
ord-c6e11644cf75409c9a739a953b702b14
出典データセット
uspto-grants-2004_05
特許番号
US06730674B2

反応ノート

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