Ethyl 2-(4-methylphenylsulfonamido)acetate → Ethyl 2-(((2-Ethoxy-2-oxoethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-iodonicotinate

HRID 1581562ノート

反応式

HRID 1581562 の反応式
Br[CH2:2][C:3]1[N:13]=[CH:12][C:11]([I:14])=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])(=[O:24])=[O:23])=[CH:18][CH:17]=1.[O-]CC.[Na+]>C(O)C>[CH2:30]([O:29][C:27](=[O:28])[CH2:26][N:25]([CH2:2][C:3]1[N:13]=[CH:12][C:11]([I:14])=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6])[S:22]([C:19]1[CH:18]=[CH:17][C:16]([CH3:15])=[CH:21][CH:20]=1)(=[O:23])=[O:24])[CH3:31]

参加物

5

反応物 3

HCID 230685Ethyl 2-(4-methylphenylsulfonamido)acetateHCID 2723922Sodium ethoxideHCID 22722039Ethyl 2-(Bromomethyl)-5-iodonicotinate

生成物 1

HCID 22722035Ethyl 2-(((2-Ethoxy-2-oxoethyl)((4-methylphenyl)sulfonyl)amino)methyl)-5-iodonicotinate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Ethyl 2-(bromomethyl)-5-iodonicotinate (Preparation 10, 9.25 g) and ethyl (((4-methylphenyl)sulfonyl)amino)acetate (7.0 g) are dissolved in anhydrous ethanol (50 mL) and a solution of sodium ethoxide (3.4 g) in ethanol (45 mL) is added over 15 min. The mixture is stirred overnight and then poured into ice water. The mixture is extracted with ethyl acetate (3×100 mL) and the organic layer is concentrated.

後処理

  1. extractionThe mixture is extracted with ethyl acetate (3×100 mL)
  2. concentrationthe organic layer is concentrated

出典と根拠

ORDレコード
ord-cc8685b670424486925ff0b9928943e4
出典データセット
uspto-grants-2004_05
特許番号
US06730682B2

反応ノート

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